Michal Granot, RN, PhD, is an associate professor at the Faculty of Social Welfare & Health Sciences, Department of Nursing, University of Haifa, Israel. Her clinical background as a midwife has shaped her research activity that focuses mainly on pain and women health by investigating the etiology, mechanism, and expression of pain modulation processes. As a member of the Haifa Pain Group at the Laboratory of Clinical Neurophysiology, Rambam Health Care Campus, Prof. Granot collaborate on projects that aim to promote transformational “lab to clinic” studies, encompassing mechanism-based tests that represent pain perception and modulation processing. She devoted part of her laboratory work to the conceptualization of a model that depicts the variability of pain experience and the plasticity of the nociceptive system.
Prof. Granot developed and use experimental-induced pain tests that mirrors inhibitory and facilitatory pain modulation pathways as well as brain activity, which involves in pain perception. She lead and take part in research projects that aim to evaluate and quantify mechanisms involved with normal, as well as altered, pain modulation responses. Her research combined assessment of brain processes during painful events, such as pain-evoked potentials, as well as the autonomic and psych-cognitive aspects of pain. Such advanced psychophysical and neurophysiological approaches enable clinicians and researchers to attain view of an individual's pain as obtained in early acute pain patients, can explain one’s risk to develop chronic pain disorders. Prof. Granot collaborate with well-known key experts in the fields of pain and gynecology with special focus on the domain of chronic pelvic pain disorders such as provoked vestibulodynia and investigate the effect of such pain on the quality of intimate relationships.
She is interest in women’s pain disorders and the mechanisms in which the ovarian hormones modulate pain processing and highlight the effect of cultural, and pain-related personality variables on pain manifestation as well as on health outcomes. She also explore pain complaints among women who were exposed to sexual abuse. Prof. Granot merge theoretical knowledge with current clinical issues and practices that require a multidimensional investigation approach in order to promote personalized medicine, based on the individual’s pathogenesis and needs. Another aspect of her activity is understanding the phenomenon of absence of pain experience in situations of injury or acute disease. For example, altered pain perception in patients with silent ischemic heart diseases. These diverse studies contain the potential to enable pain clinicians to create evidence-based guidelines for the management of chronic pain conditions, based on individually-tailored pain mechanisms.
For a full view of the publications please see the CV file.
- Drach-Zahavi, A., Goldblatt, H., Granot, M., Hirshmann, S., & Kostinsky, H. (2011). Control: Patients' Aggression in Psychiatric Settings. Qualitative Health Research, 21, 43-53. org/10.1177/1049732311414730
- Granot, M., & Wismman-Fogel, I. (2012). The effect of post-surgical neuroplasticity on the stability of systemic pain perception: a psychophysical study. European Journal of Pain, 16(2), 247-55. org/10.1016/j.ejpain.2011.07.003
- Nir, R. R., Yarnitsky, D., Honigman, L., & Granot (2012). Conditioned Pain Modulation is Reduced due to a Placebo Effect which Decreases the Subjective Perception of the Conditioning Stimulation. Pain, 153(1), 170-176. doi.org/10.1016/S1754-3207(11)70377-7]
- Yarnitsky,, Granot, M., Nahman-Averbuch, H., Khamaisi, M., & Granovsky, Y. (2012). Conditioned pain modulation predicts efficacy of duloxetine in painful diabetic neuropathy. Pain, 154(6), 1193-1198. doi.org/10.1016/j.pain.2012.02.021
- Ortner, C. M., Granot, M., Richebe, P., Cardoso, M., Bollag, L., & Landau, R. (2013). Preoperative Scar Hyperalgesia and Post-operative Pain in Women Undergoing Repeat Cesarean Delivery. European Journal of Pain, 17(1), 111-123. org/10.1002/j.1532-2149.2012.00171.x
- Wilson, H., Carvalho, B., Granot, M., & Landau, R. (2013). Evaluation of the temporal stability of conditioned pain modulation in healthy women over four menstrual cycles at the follicular and luteal phases. Pain, 154 (12), 2633-2638. org/10.1016/j.pain.2013.06.038
- Afanasiev, S., Aharon, Y., & Granot M. (2013). Personality type as a predictor for depressive symptoms and reduction in quality of life among stroke survivals. American Journal of Geriatric Psychiatry, 21(9), 832-839. org/10.1016/j.jagp.2013.04.012
- Nahman-Averbuch, H., Yarnitsky, D., Granovsky,Y., Gerber, E., Dagul, P., & Granot, M. (2013). The effect of psychophysical parameters on the conditioned pain modulation response. Scandinavian Journal of Pain, 4(1), 10-14. org/10.1016/j.sjpain.2012.08.001
- Kremer, R., Granot, M., Yarnitsky, D., Crispel, Y., Fadel, S., Best, L., & Nir, R. R. (2013). The Role of Pain Catastrophizing in the Prediction of Acute and Chronic Postoperative Pain. The Open Pain Journal, 6, 176-182. doi: 2174/1876386301306010176
- Yarnitsky, D., Granot, M., & Granovsky, Y. (2014). Pain modulation profile and pain therapy: Between pro- and antinociception. Pain, 155(4), 663-665. doi: 10.1016/j.pain.2013.11.005
- Granot, M, Dagul P., Darawsha W, & Aronson, D. (2015). Pain Modulation Efficacy Affects Delay in Seeking Medical Help in Patients with Acute Myocardial Infarction. PAIN, 156(1), 192-198. doi: 10.1016/j.pain.0000000000000020
- Yarnitsky, D., Bouhassira, D., Drewes, A., Fillingim, RB., Granot, M., Hansson, P, Landau, R., Marchand, S., Matre, D., Nielsen, KB., Stubhaug, A., Treede, R. D., & Wilder-Smith, O. (2015). Recommendations on practice of conditioned pain modulation (CPM) testing. European Journal of Pain, 19, 805-806. org/10.1002/ejp.605
- Nahman-Averbuch, H., Yarnitsky, D., Sprecher, E., Granovsky, Y., & Granot, M. (2016). Relationship between personality traits and endogenous analgesia: the role of harm avoidance. Pain Practice, 16(1), 38-45. org/10.1111/papr.12256
- Reiner, K., Granot, M., Soffer, E., & Lipsitz, J. (2016). A Brief Mindfulness Meditation Training Increases Pain Threshold and Accelerates Modulation of Response to Tonic Pain in an Experimental Study. Pain Medicine, 17, 628-635. org/10.1111/pme.12883
- Carvalho B., Granot, M., Sultan, P., Wilson , H., & Landau , R. (2016). A Longitudinal study to evaluate pregnancy-induced endogenous analgesia and pain modulation. Regional Anesthesia and Pain Medicine, 41(2), 175-180. doi: 10.1097/AAP.0000000000000359
- Dishon Benattar, Y., Omar, M., Zusman, O., Yahav, D., Zak-Doron, Y., Altunin, S., Elbaz M., Granot, M., Leibovicil, L., & Paul, M. (2016). The effectiveness and safety of high-dose colistin: prospective cohort study. Clinical Infectious Diseases, 63(12), 1605-1612. org/10.1093/cid/ciw684
- Drach-Zahavy, D., Buchnic , L. & Granot, M., (2016). Antecedents and consequences of emotional work in midwifery: A prospective field study. International Journal of Nursing Studies, 60, 168-178. doi: 10.1016/j.ijnurstu.2016.04.014
- Grinberg, K., Granot, M., Lowenstein, L., Abramov, L., & Weissman-Fogel, (2017). A common pro-nociceptive pain modulation profile typifying subgroups of chronic pelvic pain syndromes is interrelated with enhanced clinical pain. Pain, 158, 1021-1029. doi: 10.1097/j.pain.0000000000000869
- Granovsky, Y., Nahman-Averbuch, H., Khamaisi, M., & Granot, M. (2017). Efficient conditioned pain modulation despite pain persistence in painful diabetic neuropathy. Pain Reports, 2(3), e592. doi: 1097/PR9.0000000000000592
- Granot, M., Yovell, Y., Somer, E., Beny, A., Sadger, R., Uliel-Mirkin, R., & Zisman-Ilani, Y. (2018). Trauma, attachment style, and somatization: a study of women with dyspareunia and women survivors of sexual abuse. BMC Women’s Health, 18(1), 29. doi: 10.1186/s12905-018-0523-2
- Kuperman, P., Granovsky, Y., Granot, M., Bahouth, H., Fadel, S., Hyams, G., Ben Lulu, H., Aspis, O., Salame, R., Begal, J., Hochstein, D., Grunner, S., Honigman, L., Reshef, M., Sprecher, E., Bosak, N., Sterling, M., & Yarnitsky, D. (2018). Psyhophysical-psychological dichotomy in very early acute mTBI pain: A prospective study. Neurology, 91(10), e931-938. doi:1212/WNL.0000000000006120
- Grinberg, K., Granot, M., Lowenstein, L., Abramov, L., & Weissman-Fogel, I. (in press). Negative illness perceptions are associated with a pro-nociceptive modulation profile and augmented pelvic pain. Clinical Journal of Pain. Advance online publication. doi: 10.1097/AJP.0000000000000633.
- Goldblatt, H., Granot, M., & Zarbiv, E. (2019). “Death lay here on the sofa:” Reflections of young adults on their experience as caregivers of parents who died of cancer at home. Qualitative Health Research, 29, 533-544.
doi: 10.1177/1049732318800676 The first two authors contributed equally to this article.
- Granot, M., Dagul, P., Aronson, D. (2019).. Resting blood pressure modulate chest pain intensity in patients with acute myocardial infarction. Pain Reports. In press.