My research focuses on identifying novel life-style, biochemical, genetic and environmental risk factors for dementia, Alzheimer's disease, cognitive aging and stroke.

Additionally, I seek to explore circulating and imaging markers of Alzhiemer's disease in the general population. 

Weinstein G, Green MS, Keinan-Boker L. (2007). Routine screening mammography in women older than 74 years: a review of the available data. Maturitas, 57, 109-119.

Weinstein G, Goldbourt U, Tanne D. (2013). Body Height and Late-Life Cognition among Patients with Atherothrombotic Disease. Alzheimer’s Disease and Associated Disorders, 27, 145-152.

Weinstein G, Wolf PA, Beiser AS, Au R, Seshadri S. (2012). Risk Estimations, Risk Factors, and Genetic Variants Associated with Alzheimer's Disease in Selected Publications from the Framingham Heart Study. Journal of Alzheimer’s Disease, 33 Suppl 1:S439-445.

Weinstein G, Beiser AS, Au R, DeCarli C, Wolf PA, Seshadri S. (2013). Association of Parental Stroke with Brain Injury and Cognitive Measures in Offspring – The Framingham Heart Study. Stroke, 44, 812-815.

Weinstein G, Beiser AS, DeCarli C, Au R, Wolf PA, Seshadri S. (2013). Brain Imaging and Cognitive Predictors of Stroke and Alzheimer Disease in the Framingham Heart Study. Stroke, 4, 2787-2794.

Weinstein G, Seshadri S. (2014). Circulating biomarkers that predict incident dementia. Alzheimer's Research & Therapy, 6(1):6.

Weinstein G, Beiser AS, Preis RS, Chen TC, Vorgas D, Au R, Pikula A, Wolf PA, Vasan RS, Seshadri S. (2014). Serum Brain-Derived Neurotrophic Factor and Risk of Dementia: The Framingham Heart Study. JAMA Neurology, 71, 55-61.

Weinstein G, Seshadri S. Serum brain-derived neurotrophic factor as a predictor of incident dementia-reply. (2014). JAMA Neurology, 71, 653-654. Weinstein G, Goldbourt U, Tanne D (2015). Angina pectoris severity among coronary heart disease patients is associated with subsequent cognitive impairment. Alzheimer’s Disease & Associated Disorders,29, 6-11.

Williams SR, Yang Q, Chen F, Liu X, Keene K, Jacques P, Chen W, Weinstein G, Hsu F, Beiser A, Wang L, Bookman E, Doheny KF, Wolf PA, Zilka M, Selhub J, Nelson S, Worrall BB, Seshadri S, Sale MM. The Genomics and Randomized Trials Network and the Framingham Heart Study (2014). Genome-wide meta-analysis of homocysteine metabolism identifies five loci and an association of ALDH1L1 with ischemic stroke. PLoS Genetics, 10: e1004214.

Weinstein G, Preis SR, Beiser AS, Au R, Kelly-Hayes M, Kase CS, Wolf PA, Seshadri S. (2014). Cognitive Performance after Stroke – The Framingham Heart Study. International Journal of Stroke, 9 Suppl A100, 48-54.

Davies G, Armstrong N, Bis JC, Bressler J, Chouraki V, Giddaluru S, Hofer E, Ibrahim-Verbaas CA, Kirin M, Lahti J, van der Lee SJ, Le Hellard S, Liu T, Marioni RE, Oldmeadow C, Postmus I, Smith AV, Smith JA, Thalamuthu A, Thomson R, Vitart V, Wang J, Yu L, Zgaga L, Zhao W, Boxall R, Harris SE, Hill WD, Liewald DC, Luciano M, Adams H, Ames D, Amin N, Amouyel P, Assareh AA, Au R, Becker JT, Beiser A, Berr C, Bertram L, Boerwinkle E, Buckley BM, Campbell H, Corley J, De Jager PL, Dufouil C, Eriksson JG, Espeseth T, Faul JD, Ford I, Scotland G, Gottesman RF, Griswold ME, Gudnason V, Harris TB, Heiss G, Hofman A, Holliday EG, Huffman J, Kardia SL, Kochan N, Knopman DS, Kwok JB, Lambert JC, Lee T, Li G, Li SC, Loitfelder M, Lopez OL, Lundervold AJ, Lundqvist A, Mather KA, Mirza SS, Nyberg L, Oostra BA, Palotie A, Papenberg G, Pattie A, Petrovic K, Polasek O, Psaty BM, Redmond P, Reppermund S, Rotter JI, Schmidt H, Schuur M, Schofield PW, Scott RJ, Steen VM, Stott DJ, van Swieten JC, Taylor KD, Trollor J, Trompet S, Uitterlinden AG, Weinstein G, Widen E, Windham BG, Jukema JW, Wright AF, Wright MJ, Yang Q, Amieva H, Attia JR, Bennett DA, Brodaty H, de Craen AJ, Hayward C, Ikram MA, Lindenberger U, Nilsson LG, Porteous DJ, Räikkönen K, Reinvang I, Rudan I, Sachdev PS, Schmidt R, Schofield PR, Srikanth V, Starr JM, Turner ST, Weir DR, Wilson JF, van Duijn C, Launer L, Fitzpatrick AL, Seshadri S, Mosley TH Jr, Deary IJ. (2015). Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53949). Molecular Psychiatry, 20(2), 183-192.

Chouraki V, Beiser AS, Younkin L, Preis SR, Weinstein G, Hansson O, Skoog I, Lambert JC, Au R, Launer L, Wolf PA, Younkin S, Seshadri S. (2015). Plasma amyloid β and risk of Alzheimer's disease in the Framingham Heart Study. Alzheimers & Dementia, 11(3), 249-257.

Haratz S, Weinstein G, Molshazki N, Schnaider Beeri M, Ravona-Springer R, Goldbourt U, Tanne D. (2015). Impaired Cerebral Hemodynamics and Cognitive Performance in Patients with Atherothrombotic Disease. Journal of Alzheimer’s Disease, 46(1), 137-144.

Chauhan G, Adams HH, Bis JC, Weinstein G, Yu L, Töglhofer AM, Smith AV, van der Lee S, Gottesman RF, Thomson R, Wang J, Yang Q, Niessen WJ, Lopez OL, Becker JT, Phan TG, Beare RJ, Arfanakis K, Fleischman D, Vernooij MW, Mazoyer B, Schmidt H, Srikanth V, Knopman DS, Jack CR, Jr., Amouyel P, Hofman A, DeCarli C, Tzourio C, van Duijn CM, Bennett DA, Schmidt R, Longstreth WT, Jr., Mosley TH, Fornage M, Launer LJ, Seshadri S, Ikram MA, Debette S. (2015). Association of Alzheimer disease GWAS loci with MRI-markers of brain aging. Neurobioly of Aging, 36(4), 1765.e7-16.

Molshatzki N, Weinstein G, Streifler JY, Goldbourt U, Tanne D. (2015). Serum Uric Acid and Cognitive Performance in Patients with Pre-existing Atherosclerotic Disease. PLoS One, 10(3): e0120862.

Weinstein G, Maillard P, Himali JJ, Beiser AS, Au R, Wolf PA, Seshadri S, Decarli C. (2015). Glucose indices are associated with cognitive and structural brain measures in young adults. Neurology, 84(23), 2329-2337.

=Camargo EC, Weinstein G=, Beiser A, Tan ZS, DeCarli C, Kelly-Hayes M, Kase C, Murabito JM, Seshadri S. Association of Physical Function with Clinical and Subclinical Brain Disease: The Framingham Offspring Study. (2016). Journal of Alzheimers Disease, 14, 53(4):1597-1608.

Weinstein G, Beiser AS, Preisa SR, Courchesnea P, Chourakia V, Levy D, Seshadri S (2016). Plasma clusterin levels and risk of dementia, Alzheimer’s disease and stroke. Alzheimer’s & Dementia (Amst), 3, 103-109.

Weinstein G (2016). Childhood conditions and current physical performance among non-institutionalized individuals aged 50+ in Israel. European Journal of Ageing, 13(4), 335-347.

Weinstein G, Preis SR, Beiser AS, Kaess B, Chen TC, Satizabal CL, Rahman F, Benjamin EJ, Ramachandran VS, Seshadri S (2017). Clinical and Environmental Correlates of Serum BDNF: A descriptive study with plausible implications for AD research. Current Alzheimer’s Research, 14(7):722-730.

Weinstein G, Lutski M, Goldbourt U, Tanne D (2017). C-reactive protein is related to future cognitive impairment and decline in elderly with cardiovascular disease. Archives of Gerontology and Geriatrics, 69:31-37.

Lutski M, Weinstein G, Goldbourt U, and Tanne D (2017). Insulin resistance and future cognitive performance and cognitive decline in elderly patients with cardiovascular disease. Journal of Alzheimer’s Disease, 57(2):633-643.

Salinas J, Beiser AS, Himali JJ, Satizabal CL, Aparicio HJ, Weinstein G, Berkman LF, Rosand J, Seshadri S (2017). Associations between social relationship measures, serum brain-derived neurotrophic factor, and risk of stroke and dementia. Alzheimer’s & Dementia (N Y), 3(2):229-237.

Wallin A, Kapaki E, Boban M, Engelborghs S, Hermann DM, Huisa B, Jonsson M, Kramberger MG,Lossi L, Malojcic B, Mehrabian S, Merighi A, Mukaetova-Ladinska EB, Paraskevas G, Popescu BO, Ravid R, Traykov L, Tsivgoulis G, Weinstein G, Korczyn A, Bjerke M, Rosenberg G (2017). Biochemical markers in Vascular Cognitive Impairment associated with Subcortical Small Vessel Disease – A Consensus Report. BMC Neurology, 17(1):102.

Chouraki V, Preis SR, Yang, Q, Beiser A, Li S, Larson MG, Weinstein G, Wang TJ, Gerszten RE, Vasan RS, Seshadri S (2017). Association of amine biomarkers with incident dementia and Alzheimer's disease in the Framingham Study. Alzheimer’s & Dementia, 13(12):1327-1336.

Weinstein G, Zelber-Sagi S, Preis SR, Beiser AS, DeCarli C, Speliotes EK, Satizabal CL, Vasan RS, Seshadri S (2018). Association of Nonalcoholic Fatty Liver Disease with Lower Brain Volume in Healthy Middle-aged Adults in the Framingham Study. JAMA Neurology, 75(1):97-104.

Lutski M, Weinstein G, Goldbourt U, Tanne D (2018). Cardiovascular Health and Cognitive Decline 2 Decades Later in Men with Preexisting Coronary Artery Disease. American Journal of Cardiology, 121(4):410-415.

Weinstein G, Lutski M, Goldbourt U, and Tanne D (2018). Physical frailty and cognitive function among men with cardiovascular disease. Archives of Gerontology and Geriatrics, 78:1-6.

Lutski M, Haratz S, Weinstein G, Goldbourt U, Tanne D (2018). Impaired Cerebral Hemodynamics and Frailty in Patients with Cardiovascular Disease. The journals of gerontology. Series A, Biological sciences and medical sciences. 73(12):1714-1721.

Weinstein G, Elran Barak R, Beeri MS, Ravona-Springer R (2018). Personality traits and cognitive function in old-adults with type-2 diabetes. Aging and Mental Health. 23(10):1317-1325.

Lutski M, Weinstein G, Goldbourt U, Tanne D (2018). Plasma lipids, apolipoproteins, and subsequent cognitive decline in men with coronary heart disease. Journal of Alzheimer’s 67(3):827-837.

Elran Barak R, Weinstein G, Beeri MS, Ravona-Springer R (2018). The associations between objective and subjective health among older adults with type 2 diabetes: The role of personality. Journal of Psychosomatic Research. 117:41-47.

Weinstein G, Davis-Plourde KL, Conner S, Himali JJ, Beiser AS, Lee A, Rawlings AM, Sedaghat S, Ding J, Moshier E, van Duijn CM, Beeri MS, Selvin E, Ikram MA, Launer LJ, Haan MN, Seshadri S (2019). Association of metformin, sulfonylurea and insulin use with brain structure and function and risk of dementia and Alzheimer's disease: Pooled analysis from 5 cohorts. PLoS One. 14(2): e0212293.

Weinstein G, Davis-Plourde K, Himali JJ, Zelber-Sagi S, Beiser AS, Seshadri S (2019). Non-alcoholic fatty liver disease, liver fibrosis score and cognitive function in middle-aged adults: The Framingham Study. Liver International. 39(9):1713-1721.

Weinstein G, Davis-Plourde KL, Beiser AS, Seshadri S (2020). Author response: Non-alcoholic fatty liver disease, liver fibrosis score and cognitive function in middle-aged adults: The Framingham study. Liver International. 40(5):1240 (one page).

Lutski M, Weinstein G, Tanne D, Goldbourt U (2020). Angina pectoris severity and late-life frailty among men with cardiovascular disease. Aging Male. 23(5):1022-1029.

Weinstein G, Lutski M, Goldbourt U, Tanne D (2020). Midlife resting heart rate, but not its visit-to-visit variability, is associated with late-life frailty status in men with coronary heart disease. Aging Male. 23(5):1052-1058.

Lutski M, Weinstein G, Goldbourt U, Tanne D (2020). Adherence to Mediterranean diet and subsequent cognitive decline in men with cardiovascular disease. Nutritional Neuroscience. 25(1):91-99.

Sznitman S, Vulfsons S, Meiri D, Weinstein G (2020). Medical Cannabis and Insomnia in Older Adults with Chronic Pain: a Cross-Sectional Study. BMJ Supportive & Palliative Care. 10(4):415-420.

Weinstein G, Sznitman SR. The implications of late-life cannabis use on brain health: A mapping review and implications for future research. Ageing Res Rev. 2020;59:101041 (8 pages).

Schwartz E and Weinstein G (2020). Early-life food deprivation and cognitive performance among old-age Europeans. Maturitas. 141:26-32.

Vered S^#, Paz S, Negev M, Tanne D, Zucker I and Weinstein G (2020). High ambient temperature in summer and risk of stroke or transient ischemic attack: A national study in Israel. Environ Res; 187:109678 (6 pages).

Kodesh A, Goldberg Y, Rotstein A, Weinstein G, Reichenberg A, Sandin S and Levine SZ (2020). Risk of dementia and death in very-late-onset schizophrenia-like psychosis: A national cohort study. Schizophrenia research. 223:220-226.

Sznitman SR, Vulfsons S, Meiri D, and Weinstein G (2020). Medical cannabis and cognitive performance in middle to old adults treated for chronic pain. Drug and Alcohol Review. 40(2):272-280.

Shuval K, Sahar L, Gabriel KP, Knell G, Weinstein G, Gafni Gal T^#, Lobelo F, DiPietro L (2020). Sedentary Behavior, Physical Inactivity, and Metabolic Syndrome: Pilot Findings From the Rapid Assessment Disuse Index Study. J Phys Act Health. 17(10):1042-1046.

=Li S, Weinstein G=, Zare H, Teumer A, Völker U, Friedrich N, Knol MJ, Satizabal CL, Petyuk VA, Adams HHH, Launer LJ, Bennett DA, De Jager PL, Grabe1 HJ, Ikram MA, Gudnason V, Yang Q and Seshadri S (2020). The genetics of circulating BDNF: towards understanding the role of BDNF in brain aging. Brain Communication. 2(2):fcaa176 (17 pages).

Lutski M, Weinstein G, Tanne D, Goldbourt U (2020). Overweight, obesity and late-life sarcopenia in men with cardiovascular disease. Preventing Chronic Disease. 17:E164 (11 pages).

Weinstein G, Lutski M, Keinan-Boker L, Goldbourt U, and Tanne D (2021). Holocaust exposure and late-life cognitive performance in Men with Coronary Heart Disease. J Psychiatr Res. 134:1-7.

de Erausquin GA, Snyder H, Carrillo M, Hosseini AA, Brugha TS, Seshadri S; CNS SARS-CoV-2 Consortium (2021). The chronic neuropsychiatric sequelae of COVID-19: The need for a prospective study of viral impact on brain functioning. Alzheimers Demen 17(6):1056-1065.

Weinstein G, Davis-Plourde K, Beiser AS, Seshadri S. Autonomic Imbalance and Risk of Dementia and Stroke: The Framingham Study. Stroke. 2021; 52(6):2068-2076.

Weinstein G, Cohn-Schwartz E, Damri N (2021). Book-oriented environment in childhood and current cognitive performance among old-aged Europeans. Dement Geriatr Cogn Disord. 50(3):274-282.

Gafni-Gal T^#, Shuval K, Weinstein G, Gabriel KP, Wright Beth, Benjamin L. Willis, MD, David Leonard, William Haskell, Laura DeFina (2022). Sitting Time, Physical Activity, and Cognitive Impairment in Midlife and Older Adults. J Aging Phys Act. 30(3):355-363.

Spartano NL, Himali JJ, Trinquart L, Yang Q, Weinstein G, Satizabal CL, Dukes KA, Beiser AS, Murabito JM, Vasan RS, Seshadri S (2021). Accelerometer-measured, habitual physical activity and circulating brain derived neurotrophic factor: A cross-sectional study. J Alzheimers Dis. 85(2):805-814.

Weinstein G, O'Donnell A, Davis-Plourde K, Zelber-Sagi S, Ghosh S, DeCarli CS, Thibault EG, Sperling RA, Johnson KA, Beiser AS and Seshadri S (2022). Non-alcoholic fatty liver disease, liver fibrosis, and regional amyloid-β and tau pathology in middle-aged adults: the Framingham Study. J Alzheimers Dis. 86(3):1371-1383.

Weinstein G, Vered S^#, Ivancovsky-Wajcman D, Ravona Springer R, Heymann A, Zelber-Sagi S, Shahar DR and Beeri Consumption of ultra-processed food and cognitive decline among older adults with type 2 diabetes (2022). J Gerontol A Biol Sci Med Sci. 2023 Jan 26;78(1):134-142.

Bellenguez C, Küçükali F, Jansen IE… Weinstein G (collaborator) et al (>100 co-authors)(2022). New insights into the genetic etiology of Alzheimer's disease and related dementias. Nat Genet. 54(4):412-436.

Gabriel A. de Erausquin, Heather Snyder, Traolach S. Brugha, Sudha Seshadri, Maria Carrillo, Rajesh Sajar, Yueqin Huang, Charles Newton, Richard Lipton, Kameshwar Prasad, Mindy Katz, Peter Fox, Carlos Cruchaga, Ole Mors, Giovanni D’Avossa, John Bankart, Akram Hosseini, Carmela Tartaglia, Charlotte Teunissen, Krister Håkanson, Per minder Sachdev, Ingmar Skoog, Mohammad Zia Katschu, Galit Weinstein, John Blangero, Gabriela Gonzalez-Aleman,George D. Vavougios, M. Sriram Iyengar, Vincenzina Lo Re, Filippo Martinelli Boneschi, Golo Kroenenberg, Timothy Girard, Abdul Majid, Nandini Chakraborty, Ekkehart Staufenberg, Hector Gonzalez, Alfredo Ramirez, Jacques Hugon, Paul Edison, Elizabeta Mukaetova-Ladinska, Rachel Jenkins, Dan J. Stein, Rufus Akinyemi, Venos Mavreas, Mirjam Geerlings, William T. Longstreth, Paul Mullins, Alberto Salmoraighi, Carol Brayne, Heike Hesse, Igor Zwir, Vasantha Padma, Ovais Wadoo, Srishti Shreshta, Debby Tsuang, Nino Valishvili, Sophia Wang, Vibuthi Patel, Anand Pria, Sarah Williams Blangero, Gladys Maestre, Agustin Ruiz, Luis I. Brusco, Guillermo Rivera, Rodrigo Becerra, Sylvia Kaaya, Pascal Felix, Carla Gallo, Vijayalakshmi Ravindranath, Sebastian Koehler, Solomon Teferra, Juan M. Santos, Agustín Yécora, Catterina Ferreccio, Dickens Akena, Antonio Caballero, Timothy M. Hughes, Prabha Siidarth, Jennifer Manly, Mariana Figueredo-Aguiar, Kaarin Anstey, Josheph Kambeitz, Hidenori Arai, Kazuyuki Nakagome, Masahito Yamada, Takeshi Iwatsubo, Takashi Yamamura, Norrina Allen, Emily B. Levitan, Stella Panos (2022). Chronic Neuropsychiatric Sequelae of SARS-CoV2: Protocol and Methods from the Alzheimer’s Association Global Consortium. Alzheimer's & Dementia. 8(1):e12348.

Gafni T^#, Gabriel KP, Shuval K, Yaffe K, Sidney S, loyd-Jones DM and Weinstein G (2022). Physical Activity Trajectories, Autonomic Balance and Cognitive Function: the CARDIA Study. Prev Med. 164:107291.

Lutski M, Shahar R, Zucker I and Weinstein G (2023). Hospitalizations surrounding dementia diagnosis- a nation-based study. Int J Geriatr Psychiatry. 2023 Jan;38(1):e5871.

Lutski M, Weinstein G, Goldbourt U, Tanne D (2022). Peripheral sensory nerve function, type 2 diabetes and frailty among men with cardiovascular disease. J Diabetes Complications. 2022 Dec;36(12):108337.